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Main Title: The effect of alterations of schizophrenia-associated genes on gamma band oscillations
Author(s): Metzner, Christoph
Mäki-Marttunen, Tuomo
Karni, Gili
McMahon-Cole, Hana
Steuber, Volker
Type: Article
Abstract: Abnormalities in the synchronized oscillatory activity of neurons in general and, specifically in the gamma band, might play a crucial role in the pathophysiology of schizophrenia. While these changes in oscillatory activity have traditionally been linked to alterations at the synaptic level, we demonstrate here, using computational modeling, that common genetic variants of ion channels can contribute strongly to this effect. Our model of primary auditory cortex highlights multiple schizophrenia-associated genetic variants that reduce gamma power in an auditory steady-state response task. Furthermore, we show that combinations of several of these schizophrenia-associated variants can produce similar effects as the more traditionally considered synaptic changes. Overall, our study provides a mechanistic link between schizophrenia-associated common genetic variants, as identified by genome-wide association studies, and one of the most robust neurophysiological endophenotypes of schizophrenia.
Subject(s): biomarkers
neural circuits
Issue Date: 28-Apr-2022
Date Available: 27-Jun-2022
Language Code: en
DDC Class: 150 Psychologie
Sponsor/Funder: TU Berlin, Open-Access-Mittel – 2022
Journal Title: Schizophrenia
Publisher: Springer Nature
Volume: 8
Article Number: 46
Publisher DOI: 10.1038/s41537-022-00255-7
EISSN: 2754-6993
TU Affiliation(s): Fak. 4 Elektrotechnik und Informatik » Inst. Softwaretechnik und Theoretische Informatik » FG Neuronale Informationsverarbeitung
Appears in Collections:Technische Universität Berlin » Publications

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